(Reporter Zhang Xiaocheng, correspondent Yi Xiaofeng) Recently, Harbin Medical University researchers found that bilberry extract flavonol, procyanidins, quinones, phenols and other active ingredients, can significantly inhibit the proliferation of colorectal cancer cells, reduce their invasion and Transfer ability.
Bilberry is a perennial shrub native to northern Europe, North America and other places. In the 1980s, we began to introduce and acclimate blueberries. Worldwide, bilberry has been used for the treatment of diabetes and eye diseases. With the increasing number of studies on bilberry, its extensive anti-tumor effect has gradually attracted attention. This is generally thought to be related to procyanidins and other phenolic and non-phenolic components.
Liu Ming, professor of oncology surgery at the Fourth Affiliated Hospital of Harbin Medical University, prepared the bilberry extract as a phytochemical that could be used in the large intestine to simulate the physical and chemical environment of the human digestive tract in vitro and studied the chemopreventive effects of bilberry in the digestive tract. The experimental results show that the bilberry extract can significantly inhibit the proliferation of colorectal cancer cells, effectively resist the invasion and metastasis of colorectal cancer cells, and has a significant protective effect on hydrogen peroxide-induced colorectal cancer cells DNA damage. In a certain concentration range, these positive effects are time-dependent and concentration-dependent. The experiment also found that bilberry extract can arrest the growth cycle of colorectal cancer cells in G0-G1 phase, and can significantly reduce the expression of vascular endothelial growth factor in tumor cells.
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