Studies at home and abroad have shown that animals have a wide range between the normal requirements for zinc and the dose of toxic, and pigs can tolerate 20 to 30 times the normal requirements. At the same time, the tolerated dose is also related to the form of adding zinc source. When high-dose inorganic zinc compounds (such as zinc oxide, zinc sulfate) are used, it is less likely to cause zinc poisoning in animals than organic zinc. Among the inorganic zinc compounds, the application of high zinc (2000-3000 mg/kg) in the form of zinc oxide has the effect of promoting piglet growth and preventing post-weaning diarrhea in piglets, except that zinc oxide itself has astringent and weak antibacterial effects, possibly with oxidation. The biological potency of zinc is lower than that of zinc sulfate, zinc carbonate and zinc chloride, which is less likely to cause poisoning.
However, long-term feeding of high-zinc diets for livestock and poultry will have adverse effects on the development of the livestock industry and the ecological environment, and should therefore be given high priority. According to the Ministry of Agriculture of China, the amount of zinc in the form of zinc oxide in the compound feed in the first two weeks after weaning is not more than 2250 mg/kg.
Zinc oxide is highly chemically active and can react with a variety of organic substances (including organic matter in bacteria) to kill most bacteria and viruses.
After the piglets are weaned, the feed intake changes from a liquid to a solid, and the intestinal villi and intestinal epithelial cells are severely damaged. Zinc oxide can enhance the metabolism of nucleic acids and proteins by affecting the synthesis and level of biologically active substances such as insulin and zinc finger proteins. On the other hand, it promotes the proliferation and division of intestinal villi and intestinal epithelial cells through zinc finger proteins, and quickly repairs weaning due to piglets. Intestinal mucosa and villus damage caused by stress, effectively treating gastrointestinal ulcers caused by weaning stress. At the same time, it inhibits the growth of harmful bacteria and maintains the balance of intestinal flora.
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