3 Discussion of the liver as the main inactivation site of thyroid hormone and the production of thyroid hormone binding protein organs, the regulation of thyroid hormone is important for liver disease, the conversion and metabolism of thyroid hormone will be affected, so that the hypothalamic pituitary thyroid axis The regulation function was affected. The thyroid hormone changes in 165 patients with liver disease were significantly different (P <0.05 or 0.01), but there was no obvious hypothyroidism in the clinic, indicating that the T3FT3 content was reduced. The severity of the disease is closely related and is consistent with "low T3 syndrome.
The main cause of "low T3 syndrome" is that liver disease causes 5'-iodinase to be inhibited and activity is weakened, and T4 is converted into T3 disorder in the liver, which reduces the formation of T3FT3, leading to low T3 syndrome. The low T3 syndrome of liver disease has clinical significance: 1 liver disease serum T3FT3 is reduced, the body's catabolic rate is decreased, and heat consumption is reduced. It is an intrinsic self-protective mechanism of the body's self-regulating energy preservation. 2 Serum TiFT3 content The decrease was positively correlated with the degree of liver damage. As the liver function improved during treatment, the TiFT3 content gradually increased and returned to normal. Therefore, the determination of serum TiFT3 content has a certain clinical value for the degree of injury in patients with liver disease, observation of curative effect and prognosis.
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